Muaj ob hom kev hloov pauv loj, autologous thiab allogeneic qia cell hloov.
Dr Nada Hamad, Haematologist & tus kws kho mob pob txha pob txha
St Vincent's Tsev Kho Mob, Sydney
Stem cell yog dab tsi?
- Cov qe ntshav dawb (xws li lymphocytes - uas yog cov hlwb uas thaum tig qog nqaij hlav ua rau lymphoma)
- Ntshav liab (cov no yog lub luag haujlwm nqa oxygen ncig lub cev)
- Platelets (cov hlwb uas pab ntshav txhaws lossis tiv thaiv kom tsis txhob txhaws)
Dab tsi yog kev hloov pauv ntawm cov qia?
Kev hloov pauv ntawm qia cell yog ib txoj kev uas yuav siv tau los kho cov qog ntshav qog ntshav. Lawv tuaj yeem siv los kho cov neeg mob uas nws cov qog ntshav qab zib tau raug zam tab sis muaj feem ntau cov qog ntshav qab zib yuav rov qab los (rov qab los). Lawv kuj tseem siv tau los kho cov neeg mob uas lymphoma tau rov qab los (rov qab los).
Kev hloov ntawm qia cell yog ib txoj kev nyuaj thiab cuam tshuam uas tshwm sim hauv theem. Cov neeg mob uas tau hloov cov qia cell yog thawj zaug npaj nrog kev kho mob ib leeg lossis ua ke nrog kev kho hluav taws xob. Kev kho mob chemotherapy siv nyob rau hauv qia cell transplants yog muab nyob rau hauv ntau dua koob tshuaj tshaj li niaj zaus. Qhov kev xaiv ntawm chemotherapy muab rau theem no yog nyob ntawm hom thiab lub hom phiaj ntawm kev hloov pauv. Muaj peb qhov chaw uas qia hlwb rau kev hloov pauv tuaj yeem sau los ntawm:
Cov pob txha hlwb: qia hlwb raug sau ncaj qha los ntawm cov pob txha pob txha thiab hu ua a 'Bone Marrow Transplant' (BMT).
Peripheral qia hlwb: qia hlwb raug sau los ntawm cov ntshav peripheral thiab qhov no yog hu ua a 'peripheral blood stem cell transplant' (PBSCT). Qhov no yog qhov feem ntau ntawm cov qia hlwb siv rau kev hloov pauv.
Ntshav qab zib: Cov qia hlwb raug sau los ntawm txoj hlab ntaws tom qab yug me nyuam. Qhov no hu ua a 'kab ntshav hloov', qhov twg cov no tsis tshua muaj ntau dua li peripheral lossis pob txha pob txha hloov.
Hom kev hloov ntawm qia cell
Muaj ob hom kev hloov pauv loj, autologous thiab allogeneic qia cell hloov.
Autologous qia cell transplants: hom kev hloov pauv no siv tus neeg mob tus kheej qia hlwb, uas tau sau thiab khaws cia. Tom qab ntawd koj yuav muaj tshuaj kho mob siab thiab ua raws li qhov no koj cov qia hlwb yuav muab rov qab rau koj.
Allogeneic qia cell hloov pauv: hom kev hloov pauv no siv cov qia hlwb pub dawb. Tus neeg pub dawb yuav muaj feem cuam tshuam (ib tsev neeg) lossis tus neeg tsis muaj feem cuam tshuam. Koj cov kws kho mob yuav sim thiab nrhiav tus neeg pub dawb uas nws lub hlwb sib phim rau tus neeg mob. Qhov no yuav txo qhov kev pheej hmoo ntawm lub cev tsis lees txais cov kab mob pub dawb. Tus neeg mob yuav muaj tshuaj kho mob siab thiab qee zaum radiotherapy. Tom qab qhov no, cov qia hlwb pub dawb yuav muab rov qab rau tus neeg mob.
Yog xav paub ntxiv txog txhua hom kev hloov pauv no, saib autologous hloov or nplooj ntawv allogeneic hloov pauv.
Cov lus qhia rau kev hloov cov qia cell
Dr Amit Khot, Haematologist & tus kws kho mob pob txha pob txha
Peter MacCallum Cancer Center & Royal Melbourne Tsev Kho Mob
Feem ntau cov neeg mob kuaj mob lymphoma ua TSIS xav tau ib tug stem cell hloov. Ob leeg autologous thiab allogeneic qia cell transplantation tsuas yog siv nyob rau hauv tej yam xwm txheej. Cov lus qhia tseem ceeb rau kev hloov cov qia cell muaj xws li:
- Yog tias tus neeg mob lymphoma muaj ua kom dua lymphoma (lymphoma uas tsis teb rau kev kho mob) los yog rov qab los lymphoma (lymphoma uas yuav rov qab los tom qab kho).
- Cov lus qhia rau kev hloov pauv autologous (tus kheej lub hlwb) kuj txawv rau qhov qhia txog kev hloov pauv ntawm allogeneic (cov hlwb pub dawb).
- Cov neeg mob Lymphoma feem ntau tau txais kev hloov pauv autologous es tsis yog kev hloov pauv allogeneic. Kev hloov pauv autologous muaj tsawg dua kev pheej hmoo thiab tsis tshua muaj teeb meem thiab feem ntau ua tiav hauv kev kho cov qog ntshav qog ntshav.
Cov lus qhia rau kev hloov pauv autologous (tus kheej lub hlwb) qia cell muaj xws li:
- Yog tias lymphoma relapses (rov qab los)
- Yog tias lymphoma refractory (tsis teb rau kev kho mob)
- Qee cov neeg mob uas tau kuaj pom tus kab mob qog nqaij hlav uas paub tias muaj feem yuav rov qab los, lossis yog tias cov qog ntshav qog ntshav siab tshwj xeeb, yuav raug txiav txim siab rau kev hloov pauv autologous ua ib feem ntawm cov phiaj xwm pib kho.
Indications rau ib qho allogeneic (tus pub dawb) qia cell hloov muaj xws li:
- Yog hais tias tus lymphoma relapses tom qab ib tug autologous (tus kheej hlwb) qia cell hloov
- Yog hais tias lymphoma yog refractory
- Raws li ib feem ntawm kev kho mob thib ob lossis thib peb rau kev rov qab mob qog ntshav qog ntshav / CLL
Txoj kev hloov pauv
Dr Amit Khot, Haematologist & tus kws kho mob pob txha pob txha
Peter MacCallum Cancer Center & Royal Melbourne Tsev Kho Mob
Muaj tsib kauj ruam tseem ceeb uas koom nrog hauv kev hloov pauv:
- Kev npaj
- Kev sau cov qia hlwb
- Txias
- Reinfusing qia cell
- Kev Koom Tes
Cov txheej txheem rau txhua hom kev hloov pauv tuaj yeem sib txawv heev. Yog xav paub ntxiv:
Dr Amit Khot, Haematologist & tus kws kho mob pob txha pob txha
Peter MacCallum Cancer Center & Royal Melbourne Tsev Kho Mob
